SMU127, CAS 903864-87-9

Formulation: A crystalline solid

Formal Name: 5,6-dihydro-2-[[(4-methyl-1-piperazinyl)carbonyl]amino]-4H-cyclopenta[b]thiophene-3-carboxylic acid, ethyl ester

Purity: ≥98%

Formula Markup: C16H23N3O3S

Formula Weight: 337,4

Shelf life (days): 730

CAS Number: 903864-87-9

Notes: SMU127 is an agonist of the toll-like receptor 1/2 (TLR1/2) heterodimer.{60511} It induces NF-κB signaling in cells expressing human TLR2 (EC50 = 0.55 µM) but not cells expressing human TLR3, -4, -5, -7, or -8 when used at concentrations ranging from 0.1 to 100 µM. SMU127 induces the production of TNF-α in isolated human peripheral blood mononuclear cells (PBMCs) when used at concentrations ranging from 0.01 to 1 µM. In vivo, SMU127 (0.1 mg/animal) reduces tumor volume in a 4T1 murine mammary carcinoma model.

• Artikelnummer: CAY33147-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 33147-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK