SN-011, CAS 2249435-90-1

Formulation: A solid

Formal Name: N-[3-[[(4-fluorophenyl)sulfonyl]amino]-4-hydroxyphenyl]-[1,1′-biphenyl]-4-carboxamide

Purity: ≥98%

Formula Markup: C25H19FN2O4S

Formula Weight: 462,5

Shelf life (days): 1460

CAS Number: 2249435-90-1

Notes: SN-011 is a stimulator of interferon genes (STING) antagonist.{62428} It binds to the STING cyclic dinucleotide binding site (Kd = 4.03 nM) and inhibits 2'3'-cGAMP-induced Ifnb expression in mouse embryonic fibroblasts (MEFs), mouse bone marrow-derived macrophages (BMDMs), and human foreskin fibroblasts (HFFs; IC50s = 127.5, 107.1, and 502.8 nM, respectively). SN-011 (1 µM) impairs recruitment of IFN regulatory factor 3 (IRF3) or TANK-binding kinase 1 (TBK1) to the STING signalosome in HEK293T cells overexpressing tagged wild-type or SAVI-linked mutant STING and IRF3 or TBK1, as well as inhibits translocation of STING from the endoplasmic reticulum (ER) to the Golgi induced by herpes simplex virus 1 (HSV-1) in HFFs. In vivo, SN-011 (5 mg/kg) increases survival and reduces Ifnb mRNA levels in the Trex1-/- mouse model of Aicardi-Goutières syndrome, an autoimmune disorder characterized by constitutive activation of cGAS and IFN overproduction.

• Artikelnummer: CAY34890-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 34890-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK