SNAP 94847, CAS 487051-12-7

Formulation: A solid

Formal Name: N-[3-[1-[[4-(3,4-difluorophenoxy)phenyl]methyl]-4-piperidinyl]-4-methylphenyl]-2-methyl-propanamide

Purity: ≥98%

Formula Markup: C29H32F2N2O2

Formula Weight: 478,6

Shelf life (days): 1460

CAS Number: 487051-12-7

Notes: SNAP 94847 is an antagonist of melanin-concentrating hormone receptor 1 (MHC1; Ki = 2.2 nM for the recombinant rat receptor).{57823} It is selective for MHC1 over α1A-adrenergic and dopamine D2 receptors (Kis = 180 and 7,400 nM, respectively, for the recombinant human receptors). SNAP 94847 (20 mg/kg) increases the time mice spend in the light side of the light/dark exploration test, indicating anxiolytic-like activity.{57824} It reduces food intake and body weight, as well as plasma levels of glucose, insulin, and triglycerides, in a mouse model of high-fat diet-induced obesity when administered at a dose of 5 mg/kg in combination with the cannabinoid 1 (CB1) receptor antagonist rimonabant (Item No. 9000484).{57825}

• Artikelnummer: CAY35105-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 35105-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK