SNX-482, CAS 203460-30-4

Formulation: A solid

Formal Name: glycyl-L-valyl-L-α-aspartyl-L-lysyl-L-alanylglycyl-L-cysteinyl-L-arginyl-L-tyrosyl-L-methionyl-L-phenylalanylglycylglycyl-L-cysteinyl-L-seryl-L-valyl-L-asparaginyl-L-α-aspartyl-L-α-aspartyl-L-cysteinyl-L-cysteinyl-L-prolyl-L-arginyl-L-leucylglycyl-L-cysteinyl-L-histidyl-L-seryl-L-leucyl-L-phenylalanyl-L-seryl-L-tyrosyl-L-cysteinyl-L-alanyl-L-tryptophyl-L-α-aspartyl-L-leucyl-L-threonyl-L-phenylalanyl-L-seryl-L-aspartic acid, cyclic (7→21),(14→26),(20→33)-tris(disulfide)

Purity: ≥98%

Formula Markup: C192H274N52O60S7

Formula Weight: 4495

Shelf life (days): 1460

CAS Number: 203460-30-4

Notes: SNX-482 is a peptide originally isolated from H. gigas venom that acts as a class E/R-type voltage-sensitive calcium channel blocker (IC50 = 30 nM in 192C cells expressing human class E channels).{57113} It is selective for class E/R-type over class A and class B calcium channels (IC50s = >280 and ~800 nM, respectively), as well as the voltage-gated potassium channels Kv1.1, Kv1.2, and Kv1.4 (IC50s = >140 nM for all). SNX-482 inhibits class E/R-type calcium currents in isolated rat posterior pituitary (IC50 = 4 nM), however, it has no effect on class E/R-type calcium currents in isolated rat granule cells, retinal ganglion cells, or hippocampal pyramidal cells at concentrations up to 200 nM. Intrathecal administration of SNX-482 (0.5 µg/animal) inhibits formalin-induced neurokinin-1 (NK1) receptor internalization and cfos expression in the ipsilateral dorsal horn and reduces formalin-induced paw flinching in rats.{57114}

• Artikelnummer: CAY30988
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 30988-100
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK