Sobetirome, CAS 211110-63-3

Formulation: A solid

Formal Name: 2-[4-[[4-hydroxy-3-(1-methylethyl)phenyl]methyl]-3,5-dimethylphenoxy]-acetic acid

Purity: ≥98%

Formula Markup: C20H24O4

Formula Weight: 328,4

Shelf life (days): 1460

CAS Number: 211110-63-3

Notes: Sobetirome is an agonist of thyroid hormone receptor β (TRβ; EC50 = 7 nM in a reporter assay).{52772} It selectively binds to TRβ over TRα with Kd values of 0.1 and 1.8 nM, respectively. Sobetirome (97 nmol/kg, i.p.) increases hepatic levels of the HDL receptor SR-B1 and serum levels of C4, a marker of increased bile acid synthesis, in mice fed normal chow or high-cholesterol diets.{52773} It reduces serum cholesterol and triglyceride levels in these same models. Sobetirome (154 nmol/kg, i.p.) also decreases plasma cholesterol levels, without increasing heart rate, in a mouse model of hypothyroidism induced by an iodine-deficient diet containing the thyroid hormone biosynthesis inhibitor 5-propyl-2-thio-uracil.{52774}

• Artikelnummer: CAY30814-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 30814-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK