Somatostatin-28 (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)

Formulation: A lyophilized powder

Purity: ≥95%

Formula Markup: C137H207N41O39S3 • XCF3COOH

Formula Weight: 3148,6

Shelf life (days): 1460

Notes: Somatostatin-28 is a cyclic neuropeptide hormone that has a role in endocrine regulation.{42021} It is a somatostatin (SST) receptor agonist that binds to SST1, SST2, SST3, SST4, and SST5 (IC50s = 0.60, 0.12, 0.22, 0.83, and 0.41 nM, respectively, in CCL39 cells expressing human recombinant receptors).{42022} It inhibits cAMP accumulation induced by forskolin (Item No. 11018) in CCL39 cells expressing human recombinant SST1, SST2, SST3, SST4, and SST5 (EC50s = 5.13, 1.91, 6.46, 2.95, and 3.55 nM, respectively).{42023} Somatostatin-28 stimulates growth hormone (GH) release from primary porcine pituitary cells when used at a concentration of 1 fM.{42024} It inhibits acid secretion induced by gastrin I (Item No. 24457) and IBMX (Item No. 13347) in isolated rat gastric mucosa (EC50s = 27 and 252 nM, respectively).{42025} In vivo, somatostatin-28 dose-dependently increases basal and pentagastrin-induced gastric acid secretion in rats.{42026}

• Artikelnummer: CAY24991
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 24991-500
• Green Labware: Nein
• Verpackungseinheit: 500 µg
• Mengeneinheit: STK