Songorine, CAS 509-24-0

Formulation: A solid

Formal Name: (3R,6S,6aR,6bR,9R,11R,11aR,12R,12aR,14R)-1-ethyldodecahydro-6,11-dihydroxy-3-methyl-10-methylene-12,3,6a-ethanylylidene-9,11a-methanoazuleno[2,1-b]azocin-8(9H)-one

Purity: ≥98%

Formula Markup: C22H31NO3

Formula Weight: 357,5

Shelf life (days): 1460

CAS Number: 509-24-0

Notes: Songorine is a diterpene alkaloid that has been found in Aconitum and has diverse biological activities.{62354,62355,46695,62356} It is an antagonist of the GABAA receptor (IC50 = 7.06 µM in rat brain membranes).{62354} Songorine (20-80 µM) reduces the viability and migration of, and induces apoptosis in, SKOV3 and A2780 epithelial ovarian cancer cells.{62355} It also decreases the levels of β-catenin and phosphorylated GSK3β in the same cells and reduces tumor growth in a SKOV3 mouse xenograft model when administered at doses of 0.25 and 2.5 mg/kg. Songorine (0.025 mg/kg) prevents and inhibits paw edema in a mouse model of carrageenan-induced inflammation.{46695} It also has antinociceptive activity in the early phase of the formalin test in mice when administered at a dose of 46.4 mg/kg.{62356}

• Artikelnummer: CAY34601-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 34601-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK