Sparstolonin B, CAS 1259330-61-4

Formulation: A solid

Formal Name: 4,10-dihydroxy-3H-pyrano[3,4,5-kl]xanthen-3-one

Purity: ≥95%

Formula Markup: C15H8O5

Formula Weight: 268,2

Shelf life (days): 1460

CAS Number: 1259330-61-4

Notes: Sparstolonin B is an isocoumarin that has been found in Spaganium stoloniferum and has diverse biological activities.{61900,61901,61902,61903} It inhibits increases in TNF-α, IL-6, and IL-1β levels induced by the toll-like receptor 4 (TLR4) agonist LPS, TLR2 agonist Pam3CSK4 (Item No. 24126), or TLR2/6 agonist FSL-1 (Item No. 24220) but not the TLR3 agonist poly(I:C) or TLR9 agonist ODN1668 in primary mouse macrophages when used at a concentration of 100 µM.{61900} Sparstolonin B (1-10 µM) reduces HIV-1 p24 antigen levels in the culture supernatant of human peripheral blood mononuclear cells (PBMCs) infected with HIV-1, indicating inhibition of HIV replication.{61901} It induces apoptosis, cell cycle arrest at the G2/M phase, and production of reactive oxygen species (ROS) in SH-SY5Y neuroblastoma cells when used at a concentration of 10 µM.{61902} Sparstolonin B (3 and 9 mg/kg) protects mice from lethal endotoxin shock.{61903}

• Artikelnummer: CAY33080-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 33080-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: Reinstoffe