SR 144528-d3

Formulation: A crystalline solid

Formal Name: 5-(4-chloro-3-methylphenyl)-1-(4-(methyl-d3)benzyl)-N-((1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)-1H-pyrazole-3-carboxamide

Purity: ≥99% (dueterated forms d1-d3)

Formula Markup: C29H31D3ClN3O

Formula Weight: 479,1

Shelf life (days): 730

Notes: SR 144528-d3 is intended for use as an internal standard for the quantification of SR 144528 (Item No. 9000491) by GC- or LC-MS. SR 144528 is a cannabinoid 2 (CB2) receptor antagonist (Ki = 0.6 nM).{7912} It is selective for CB2 over CB1 receptors in CHO cells expressing the human receptors (Ki = 437 nM).{17199} SR 144528 reverses CP 55,940-induced inhibition of forskolin-induced adenylyl cyclase activity in CHO cells expressing human CB2 receptors (EC50 = 10 nM). SR 144528 (0.01 mg/kg) reduces paw swelling in a mouse model of carrageenan-induced paw edema.{14732}

• Artikelnummer: CAY37830-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37830-500
• Green Labware: Nein
• Verpackungseinheit: 500 µg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung