SR 1903, CAS 1414248-06-8

Formulation: A crystalline solid

Formal Name: 2'-methyl-4'-[[4-(4-pyridinylmethyl)-1-piperazinyl]methyl]-α,α-bis(trifluoromethyl)-[1,1'-biphenyl]-4-methanol

Purity: ≥98%

Formula Markup: C27H27F6N3O

Formula Weight: 523,5

Shelf life (days): 730

CAS Number: 1414248-06-8

Notes: SR 1903 is a modulator of retinoic acid receptor-related orphan receptor γ (RORγ) and liver X receptor (LXR).{35980} It is an inverse agonist of RORγ (IC50 = ~100 nM in a cell-based reporter assay) and an agonist of LXR. It also binds to peroxisome proliferator-activated receptor γ (PPARγ; IC50 = 209 nM) but does not activate it. SR 1903 (10 μM) inhibits LPS-induced expression of triggering receptor expressed on myeloid cells 1 (TREM-1) in RAW 264.7 cells. It also inhibits LPS-induced expression of the LXR target genes IL-6 and IL-33 and increases expression of ABCG1, FASN, and SCD-1 in RAW 264.7 cells. SR 1903 (20 mg/kg twice per day) reduces severity score in a mouse model of collagen-induced arthritis. It reduces blood glucose levels in a glucose tolerance test, serum levels of total cholesterol and LDL, body weight, and fat mass in a mouse model of high-fat diet-induced obesity.

• Artikelnummer: CAY28253-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 28253-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK