Sufugolix, CAS 308831-61-0

Formulation: A solid

Formal Name: N-[4-[1-[(2,6-difluorophenyl)methyl]-1,2,3,4-tetrahydro-5-[[methyl(phenylmethyl)amino]methyl]-2,4-dioxo-3-phenylthieno[2,3-d]pyrimidin-6-yl]phenyl]-N'-methoxy-urea

Purity: ≥95%

Formula Markup: C36H31F2N5O4S

Formula Weight: 667,7

Shelf life (days): 1460

CAS Number: 308831-61-0

Notes: Sufugolix is a gonadotropin-releasing hormone (GnRH) receptor antagonist (IC50 = 0.1 nM).{45410} Sufugolix inhibits GnRH-induced arachidonic acid (Item Nos. 90010 / 90010.1 / 10006607) release in CHO cells expressing human recombinant or monkey recombinant GnRH (IC50s = 0.1 and 10 nM, respectively), but not the rat GnRH receptor. It inhibits luteinizing hormone (LH) release stimulated by GnRH in monkey pituitary cells ex vivo (IC50 = 36 nM).{45411} Sufugolix (10 and 30 mg/kg) reduces increases in plasma LH following castration in male cynomolgus monkeys and lowers serum LH, estradiol, and progesterone levels in female cynomolgus monkeys when administered at a dose of 90 mg/kg.{45410,45411}

• Artikelnummer: CAY27996-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 27996-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK