(±)-Sulpiride, CAS 15676-16-1

Formulation: A crystalline solid

Formal Name: 5-(aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-benzamide

Purity: ≥98%

Formula Markup: C15H23N3O4S

Formula Weight: 341,4

Shelf life (days): 1460

CAS Number: 15676-16-1

Notes: (±)-Sulpiride is an atypical antipsychotic that binds to dopamine D2 and D3 receptors (Kis = 4.2 and 15 nM, respectively).{41323} It is selective for dopamine D2 and D3 over D1 receptors and the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT2A, 5-HT2C, and 5-HT3 (Kis = >10,000 nM). (±)-Sulpiride (0.5 or 1 ng per animal) increases attentional accuracy and decreases latency to respond correctly, the number of omissions, and impulsivity in the 5-choice serial reaction time task (5CSRTT) when infused directly into the nucleus accumbens in a rat model of prefrontal cortex lesion-induced attentional dysfunction.{46039} It increases cortical and striatal demethylation of hypermethylated reelin and GAD67 promoters in mice when administered at doses ranging from 12.5 to 50 μmol/kg twice per day for three days.{46040} Formulations containing (±)-sulpiride have been used in the treatment of schizophrenia.

• Artikelnummer: CAY25984-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 25984-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK