Sulthiame, CAS 61-56-3

Formulation: A solid

Formal Name: 4-(tetrahydro-1,1-dioxido-2H-1,2-thiazin-2-yl)-benzenesulfonamide

Purity: ≥95%

Formula Markup: C10H14N2O4S2

Formula Weight: 290,4

Shelf life (days): 1460

CAS Number: 61-56-3

Notes: Sulthiame is a pan-inhibitor of carbonic anhydrases (CA; Kis = 6-1,540 nM for CAI, -II, and IV-XIV) and an anticonvulsant.{64413} It is selective for these CAs over CAIII (Ki = 630 µM). Sulthiame (10 µg/ml) also inhibits voltage-gated sodium currents in isolated guinea pig hippocampal CA1 neurons.{64414} It reduces epileptiform activity induced by 4-aminopyridine (Item No. 18511) in guinea pig hippocampal slices when used at a concentration of 2.5 mM.{64415} Sulthiame (100-300 mg/kg, i.p.) induces neuronal cell death in neonatal rats.{64416} It decreases forelimb clonus duration in a rat model of partial epilepsy induced by amygdaloid kindling when administered at doses ranging from 25 to 200 mg/kg.{64417} Formulations containing sulthiame have been used in the treatment of epilepsy.

• Artikelnummer: CAY36271-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36271-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: Reinstoffe