T-5342126, CAS 956507-49-6

Formulation: A solution in methyl acetate

Formal Name: 1-[[[1-[(2-chlorophenyl)methyl]-3,5-dimethyl-1H-pyrazol-4-yl]methyl]methylamino]-3-(4-ethoxyphenoxy)-2-propanol

Purity: ≥98%

Formula Markup: C25H32ClN3O3

Formula Weight: 458

Shelf life (days): 730

CAS Number: 956507-49-6

Notes: T-5342126 is a toll-like receptor 4 (TLR4) antagonist.{54993} It reduces LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC50 = 27.8 µM), as well as decreases LPS-induced IL-8, TNF-α, and IL-6 production in isolated human whole blood (IC50s = 110.5, 315.6, and 318.4 µM, respectively). T-5342126 (82 mg/kg) reduces ethanol intake and the abundance of ionized calcium-binding adapter molecule 1 (Iba1), a marker of microglial activation, in the central nucleus of the amygdala in ethanol-dependent mice.{54994}

• Artikelnummer: CAY33099-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 33099-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK