Formulation: A solution in methyl acetate
Formal Name: 1-[[[1-[(2-chlorophenyl)methyl]-3,5-dimethyl-1H-pyrazol-4-yl]methyl]methylamino]-3-(4-ethoxyphenoxy)-2-propanol
Purity: ≥98%
Formula Markup: C25H32ClN3O3
Formula Weight: 458
Shelf life (days): 730
CAS Number: 956507-49-6
Notes: T-5342126 is a toll-like receptor 4 (TLR4) antagonist.{54993} It reduces LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC50 = 27.8 µM), as well as decreases LPS-induced IL-8, TNF-α, and IL-6 production in isolated human whole blood (IC50s = 110.5, 315.6, and 318.4 µM, respectively). T-5342126 (82 mg/kg) reduces ethanol intake and the abundance of ionized calcium-binding adapter molecule 1 (Iba1), a marker of microglial activation, in the central nucleus of the amygdala in ethanol-dependent mice.{54994}