Talnetant, CAS 174636-32-9

Formulation: A crystalline solid

Formal Name: 3-hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]-4-quinolinecarboxamide

Purity: ≥98%

Formula Markup: C25H22N2O2

Formula Weight: 382,5

Shelf life (days): 1460

CAS Number: 174636-32-9

Notes: Talnetant is an antagonist of the neurokinin-3 (NK3) receptor (Ki = 1 nM).{28052} It is selective for NK3 over NK1 and NK2 receptors (Kis = 144 and >100,000 nM, respectively, in CHO cells expressing recombinant human receptors). Talnetant inhibits calcium mobilization induced by neurokinin B (Item No. 24542) in HEK293 cells expressing human NK3 receptors (IC50 = 16.6 nM). It inhibits contractions induced by the NK3 receptor agonist senktide (Item No. 16721) in isolated rabbit iris sphincter muscle (pD2 = 9.1). Talnetant (5-20 mg/kg) reduces senktide-induced head shakes and tail whips in mice. It also inhibits senktide-induced wet-dog shakes, increases extracellular dopamine and norepinephrine in the medial prefrontal cortex, and attenuates haloperidol-induced increases in nucleus accumbens dopamine levels in guinea pigs.{53729}

• Artikelnummer: CAY29699-250
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 29699-250
• Green Labware: Nein
• Verpackungseinheit: 250 mg
• Mengeneinheit: STK