Tapinarof, CAS 79338-84-4

Formulation: A solid

Formal Name: 2-(1-methylethyl)-5-[(1E)-2-phenylethenyl]-1,3-benzenediol

Purity: ≥98%

Formula Markup: C17H18O2

Formula Weight: 254,3

Shelf life (days): 1460

CAS Number: 79338-84-4

Notes: Tapinarof is a stilbene that has been found in P. luminescens and has diverse biological activities.{51338,51339} It is active against the fungi C. tropicales, C. neoformans, and A. fumigatus (MICs = 25, 12, and 12 µg/ml, respectively) and the plant pathogenic fungi A. flavus and B. cinerea (MICs = 25 and 12 µg/ml, respectively).{51338} It induces nuclear translocation of the aryl hydrocarbon receptor (AhR; EC50 = 0.16 nM) and expression of the AhR target gene CYP1A1 in HaCaT keratinocytes when used at a concentration of 1 µM.{51339} Tapinarof (10 µM) reduces activated immune cell-induced mRNA expression of the gene encoding IL-17a in isolated human keratinocytes.{51339,34217} Formulations containing tapinarof have been used in the topical treatment of adult plaque psoriasis.

• Artikelnummer: CAY36527-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36527-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK
• Methode: Reinstoffe