Terlipressin (acetate), CAS 914453-96-6

Formulation: A crystalline solid

Formal Name: N-(glycylglycylglycyl)-8-L-lysine-vasopressin, acetate

Purity: ≥95%

Formula Markup: C52H74N16O15S2 • XC2H4O2

Formula Weight: 1227,4

Shelf life (days): 1460

CAS Number: 914453-96-6

Notes: Terlipressin is a prodrug form of the vasopressin peptide lysipressin and a partial agonist of the vasopressin V1A receptor (Ki = 0.85 µM).{47419} It is also an agonist of vasopressin V1B and V2 receptors (Kis = 1.11 and 1.58 µM, respectively). It increases mean arterial pressure (MAP) and decreases mortality in a rat model of uncontrolled hemorrhagic shock when administered at a dose of 15 µg/kg.{47420} Terlipressin (2.6 µg/kg per hour), in combination with norepinephrine, improves vascular reactivity and increases survival time in a rat model of cecal ligation and puncture-induced septic shock and a rabbit model of LPS-induced septic shock.{47421} It also increases MAP in a rat model of liver cirrhosis with portal hypertension, arterial hypotension, high cardiac output, and low systemic vascular resistance.{47422}

• Artikelnummer: CAY27027-250
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 27027-250
• Green Labware: Nein
• Verpackungseinheit: 250 mg
• Mengeneinheit: STK