Formulation: A solid
Formal Name: N-1,3,4-thiadiazol-2-yl-3-pyridinecarboxamide
Purity: ≥98%
Formula Markup: C8H6N4OS
Formula Weight: 206,2
Shelf life (days): 1460
CAS Number: 51987-99-6
Notes: TGN 020 is an aquaporin-4 (AQP4) inhibitor (IC50 = 3.1 μM in X. laevis oocytes transfected with AQP4).{60036} It reduces brain edema and cortical infarction size in a mouse model of transient focal cerebral ischemia induced by middle cerebral artery occlusion (MCAO) when administered at a dose of 200 mg/kg.{60037} TGN 020 (200 mg/kg every 6 hours) reduces bronchoalveolar lavage fluid (BALF) IL-1α, IL-1β, IL-6, TNF-α, IL-23, and IL-17A levels and neutrophil infiltration, as well as increases survival, in a mouse model of LPS-induced acute lung injury.{60038}