Theobromine-d6, CAS 117490-40-1

Formulation: A crystalline solid

Formal Name: 3,7-dihydro-3,7-di(methyl-d3)-1H-purine-2,6-dione

Purity: ≥99% deuterated forms (d1-d6)

Formula Markup: C7H2D6N4O2

Formula Weight: 186,2

Shelf life (days): 1460

CAS Number: 117490-40-1

Notes: Theobromine-d6 is intended for use as an internal standard for the quantification of theobromine (Item No. 21745) by GC- or LC-MS. Theobromine is a methylxanthine alkaloid and derivative of caffeine (Item No. 14118) that has been found in cocoa beans and has diverse biological activities.{34451,34450,34453} It is an adenosine A1 receptor antagonist (IC50s = 200-280 μM in radioligand binding assays using rat brain membranes).{34450} Theobromine (150 μg/ml) increases AMPK phosphorylation and inhibits adipocyte differentiation, ERK and JNK phosphorylation, and IL-6 and TNF-α production in 3T3-L1 preadipocytes cultured in differentiation medium.{34451} It inhibits decreases in renal cortex SIRT1 activity and increases in NADPH oxidase-dependent reactive oxygen species (ROS) production, as well as reduces kidney hypertrophy and albuminuria in a spontaneously hypertensive rat model of streptozotocin-induced diabetes when administered at a dose of 5 mg/kg per day.{34453} Theobromine is toxic to dogs with an LD50 value of 250 to 500 mg/kg.{34454}

• Artikelnummer: CAY9003565-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 9003565-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung