Thiothixene, CAS 5591-45-7

Formulation: A crystalline solid

Formal Name: N,N-dimethyl-9-[3-(4-methyl-1-piperazinyl)propylidene]-9H-thioxanthene-2-sulfonamide

Purity: ≥98%

Formula Markup: C23H29N3O2S2

Formula Weight: 443,6

Shelf life (days): 1460

CAS Number: 5591-45-7

Notes: Thiothixene is a typical antipsychotic.{39485} It selectively binds to dopamine D2 over D1, D3, and D4 receptors (Kis = 0.417, 338, 186.2, and 363.1 nM, respectively). Thiothixene also binds to various serotonin (5-HT), histamine H1, α1- and α2-adrenergic, muscarinic acetylcholine, and sigma receptors (Kis = 15-5,754 nM) as well as the dopamine, norepinephrine, and serotonin transporters (Kis = 3.16-30 μM). In vivo, thiothixene reduces spontaneous and amphetamine-induced locomotor activity in rats.{39486} It enhances latent inhibition, as measured by a decreased lick latency in response to light and foot shock stimuli, which is a measure of selective attention in rats.{39487} Thiothixene also increases competitive behavior in submissive mice, indicating antidepressant-like behavior.{39488} Formulations containing thiothixene have been used in the treatment of schizophrenia and bipolar mania.

• Artikelnummer: CAY23649-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 23649-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK