Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 5-oxo-L-prolyl-L-histidyl-L-prolinamide
Purity: ≥98%
Formula Markup: C16H22N6O4
Formula Weight: 362.4
CAS Number: 24305-27-9
Notes: Thyrotropin-releasing Hormone (TRH) is a tropic hormone that stimulates release of thyroid-stimulating hormone (TSH) and prolactin.{41462} It binds to the human TRH receptor (TRHR) expressed in CHO cells and to rat TRHR in rat brain membranes (IC50s = 25 and 198 nM, respectively).{41463,41464} TRH (1 μM) decreases polyphosphoinositide and increases arachidonic and oleic acid diacylglycerol incorporation into lipids of GH3 rat pituitary tumor cells.{41465} In vitro, it dose-dependently increases TSH release from rat anterior pituitary slices and prolactin release from cultured anterior pituitary cells.{41466,41467} In vivo, TRH (0.01 mg/kg) increases TSH and prolactin plasma levels in rats.{41462}
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