Tizanidine-d4 (hydrochloride), CAS 1188263-51-5

Formulation: A solid

Formal Name: 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl-4,4,5,5-d4)-2,1,3-benzothiadiazol-4-amine, monohydrochloride

Purity: ≥99% deuterated forms (d1-d4)

Formula Markup: C9H4ClD4N5S • HCl

Formula Weight: 294,2

Shelf life (days): 1460

CAS Number: 1188263-51-5

Notes: Tizanidine-d4 is intended for use as an internal standard for the quantification of tizanidine (Item No. 16477) by GC- or LC-MS. Tizanidine is an α2-adrenergic receptor (α2-AR) agonist.{39278} Administration of tizanidine reduces neuronal excitation induced by noxious stimuli and depresses spontaneous neuronal firing in anesthetized cats. Tizanidine-induced neuronal depression is reversed by the selective α2-AR antagonist RX781094 but not the α1-AR antagonists prazosin (Item No. 15023) and WB-4101. It acts as a muscle relaxant that inhibits α- and γ-rigidity in rats, reflex muscle tone in rabbits, and the linguomandibular reflex in cats without sedative, hemodynamic, or neurochemical effects.{39279} Formulations containing tizanidine have been used in the treatment of spasticity.

• Artikelnummer: CAY26521-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 26521-500
• Green Labware: Nein
• Verpackungseinheit: 500 µg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung