TLR7/8 Agonist 1 (hydrochloride), CAS 1620278-72-9

Formulation: A solid

Formal Name: 1-[[4-(aminomethyl)phenyl]methyl]-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine, dihydrochloride

Purity: ≥98%

Formula Markup: C22H25N5 • 2HCl

Formula Weight: 432,4

Shelf life (days): 1460

CAS Number: 1620278-72-9

Notes: TLR7/8 agonist 1 is a dual agonist of toll-like receptor 7 (TLR7) and TLR8 (EC50s = 50 and 55 nM, respectively, in cell-based assays).{47662} It increases the levels of TNF-α, IFN-γ, IL-12p40, and chemokine (C-C motif) ligand 4 (CCL4) in human peripheral blood mononuclear cells (PBMCs) in a biphasic manner. TLR7/8 agonist 1 (25 nmol, s.c.) increases serum levels of IL-12p40 and chemokine (C-X-C motif) ligand 10 (CXCL10), as well as the number of dendritic cells per injection-site proximal lymph node, in mice.{47663} It has been conjugated to various fluorophores as TLR7 probes and to polymer particles for the modulation of TLR7/8 agonist 1 adjuvant activity.{47664,47663}

• Artikelnummer: CAY28451-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 28451-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK