TM-N1324, CAS 1144477-35-9

Formulation: A solid

Formal Name: 4-(2-chloro-4-fluorophenyl)-1,4,5,7-tetrahydro-3-methyl-1-(9H-purin-6-yl)-6H-pyrazolo[3,4-b]pyridin-6-one

Purity: ≥98%

Formula Markup: C18H13ClFN7O

Formula Weight: 397,8

Shelf life (days): 1460

CAS Number: 1144477-35-9

Notes: TM-N1324 is an agonist of G protein-coupled receptor 39 (GPR39).{62810} It is selective for GPR39 over a panel of 165 GPCRs, including the growth hormone (GH) secretagogue receptor (GHS-R) and motilin receptor, at 1 µM. TM-N1324 induces inositol phosphate accumulation in HEK293 cells expressing human GPR39 (EC50s = 2 and 201 nM in the presence and absence of zinc, respectively) and cAMP accumulation in COS-7 cells expressing human GPR39 (EC50 = 17 nM in the presence of zinc). It decreases ghrelin secretion and increases somatostatin secretion in isolated mouse gastric mucosa cells when used at a concentration of 1 µM. TM-N1324 (30 mg/kg) decreases food intake during the dark period and body weight in a mouse model of high-fat diet-induced obesity.{62809}

• Artikelnummer: CAY37208-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37208-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: Reinstoffe