TMB 8 (hydrochloride), CAS 53464-72-5

Formulation: A solid

Formal Name: 3,4,5-trimethoxy-benzoic acid, 8-(diethylamino)octyl ester, monohydrochloride

Purity: ≥98%

Formula Markup: C22H37NO5 • HCl

Formula Weight: 432

Shelf life (days): 1460

CAS Number: 53464-72-5

Notes: TMB 8 is a non-competitive antagonist of nicotinic acetylcholine receptors (nAChRs) with IC50 values of 390 and 350 nM, respectively, for human muscle-type and α3β4 subunit-containing ganglionic nAChRs expressed in TE671/RD or SH-SY5Y cells.{38552} It inhibits nicotine-induced dopamine release from rat brain synaptosomes (IC50 = 480 nM). TMB 8 also reduces calcium availability in smooth and skeletal muscle, blocking the contractile response in isolated rabbit aortic strip when used at a concentration of 50 µM and inhibiting calcium influx and efflux in isolated guinea pig ileum when used at a concentration of 65 µM.{38553} It has been used in the study of intracellular calcium dynamics, particularly in smooth muscle.{38554,38555} TMB 8 also inhibits protein kinase C (PKC) activity in a dose-dependent manner.{38556}

• Artikelnummer: CAY23928-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 23928-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK