Tolazamide, CAS 1156-19-0

Formulation: A crystalline solid

Formal Name: N-[[(hexahydro-1H-azepin-1-yl)amino]carbonyl]-4-methyl-benzenesulfonamide

Purity: ≥98%

Formula Markup: C14H21N3O3S

Formula Weight: 311,4

Shelf life (days): 1460

CAS Number: 1156-19-0

Notes: Tolazamide is a first generation sulfonylurea that inhibits sulfonylurea receptor 1 (SUR1) linked to the inwardly rectifying potassium channel (KIR6.2; IC50 = 4.2 µM in HEK293 cells transfected with the human receptor).{36318} It has no effect on glucose uptake in L6 rat skeletal muscle cells when used at a concentration of 0.6 mg/mL but enhances glucose uptake two-fold when used in combination with insulin.{40738} In vivo, tolazamide (128 mg/kg) reduces glomerulosclerosis and albumin excretion in a rat model of insulin-dependent diabetes induced by streptozotocin (Item No. 13104).{40739} Formulations containing tolazamide have been used in the treatment of type 2 diabetes.

• Artikelnummer: CAY23545-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 23545-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK