TPMPA (hydrate)

Formulation: A crystalline solid

Formal Name: P-methyl-P-(1,2,3,6-tetrahydro-4-pyridinyl)-phosphinic acid, hydrate

Purity: ≥95%

Formula Markup: C6H12NO2P • XH2O

Formula Weight: 161,1

Shelf life (days): 1460

Notes: TPMPA is a GABAA-ρ1 (ρ1 GABAC) receptor antagonist that is 8-fold selective for GABAA-ρ1 over GABAA-ρ2 (ρ2 GABAC) receptors expressed in X. laevis oocytes (Kbs = 2 and 16 μM, respectively).{38978} In rat hippocampal slices, TPMPA blocks the inhibitory effect of the GABAB agonist 3-APMPA on excitatory postsynaptic currents (EPSCs) with an EC50 value of 490 μM.{38979} TPMPA (100 μM) increases light sensitivity and the maximal response of rat retinal ganglion cells without altering their dynamic range.{38980} In sleeping rats, TPMPA (50 μg, i.c.v.) increases waking from 45 to 62% compared to a vehicle control and decreases slow-wave and paradoxical sleep (REM) by 11 and 5.4%, respectively.{38981}

• Artikelnummer: CAY24302-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 24302-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK