Trabectedin, CAS 114899-77-3

Formulation: A solid

Formal Name: (1′R,6R,6aR,7R,13S,14S,16R)-5-(acetyloxy)-3′,4′,6,6a,7,13,14,16-octahydro-6′,8,14-trihydroxy-7′,9-dimethoxy-4,10,23-trimethyl-spiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1′(2′H)-isoquinolin]-19-one

Purity: ≥95%

Formula Markup: C39H43N3O11S

Formula Weight: 761,8

Shelf life (days): 1460

CAS Number: 114899-77-3

Notes: Trabectedin is an alkaloid that has been found in E. turbinata and has anticancer activity.{58747,58748,58749,58750} It is a guanine-specific DNA alkylating agent and an antagonist of the pregnane X receptor (PXR; IC50 = ~3 nM in a reporter assay).{58747,58748} Trabectedin reduces viability of DU145 and PC3 human prostate cancer stem cells in a concentration-dependent manner and induces apoptosis in DU145 and PC3 cancer stem cells and DU145 and PC3 non-stem cancer cells.{58749} It inhibits tumor growth in a patient-derived orthotopic xenograft (PDOX) mouse model of leiomyosarcoma when administered at a dose of 0.15 mg/kg per week.{58750} Formulations containing trabectedin have been used in the treatment of unresectable or metastatic liposarcoma or leiomyosarcoma.

• Artikelnummer: CAY34662-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 34662-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK