Formulation: A solid
Formal Name: α-cyclohexyl-α-phenyl-1-piperidinepropanol, monohydrochloride
Purity: ≥98%
Formula Markup: C20H31NO • HCl
Formula Weight: 337,9
Shelf life (days): 1460
CAS Number: 52-49-3
Notes: Trihexyphenidyl is an antagonist of M1 muscarinic acetylcholine receptors.{45595} It binds to rat M1 receptors in cerebral cortex selectively over rat M2 receptors in heart tissue (IC50s = 3.7 and 31 nM, respectively). Trihexyphenidyl inhibits contractions induced by acetylcholine (Item No. 23829) in guinea pig ileum (IC50 = 22 nM).{46375} It also inhibits oxotremorine-induced tremors and physostigmine-induced mortality in mice (ED50s = 2 and 3.6 mg/kg, respectively). Trihexyphenidyl (20 mg/kg) improves abnormal movement in a mouse model of L-3,4-dihydroxyphenylalanine (L-DOPA) responsive dystonia (DRD) that expresses mutant tyrosine hydroxylase (TH).{45596} Formulations containing trihexyphenidyl have been used in the symptomatic treatment of Parkinson's disease.