Trimipramine N-oxide, CAS 14171-70-1

Formulation: A solid

Formal Name: 10,11-dihydro-N,N,β-trimethyl-5H-dibenz[b,f]azepine-5-propanamine N-oxide

Purity: ≥90%

Formula Markup: C20H26N2O

Formula Weight: 310,4

Shelf life (days): 1460

CAS Number: 14171-70-1

Notes: Trimipramine N-oxide is an active metabolite of the tricyclic antidepressant trimipramine (Item No. 15921).{67010} It is formed via N-oxidation of trimipramine by the cytochrome P450 (CYP) isoforms CYP2D6, CYP2C9, CYP2C19, CYP1A2, and CYP3A4. Trimipramine N-oxide selectively inhibits the serotonin transporter (SERT) over organic cation transporter 1 (OCT1) and OCT2, the dopamine transporter (DAT), and the norepinephrine transporter (NET) in HEK293 cells expressing the human transporters (IC50s = 3.59, 9.35, 27.4, 9.4, and 11.7 µM, respectively).

• Artikelnummer: CAY35414-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 35414-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK
• Methode: Reinstoffe