Triptorelin (trifluoroacetate salt), CAS 2240176-35-4

Formulation: A solid

Formal Name: 6-D-tryptophan-luteinizing hormone-releasing factor (swine), trifluoroacetate

Purity: ≥98%

Formula Markup: C64H82N18O13 • XCF3COOH

Formula Weight: 1311,4

Shelf life (days): 1460

CAS Number: 2240176-35-4

Notes: Triptorelin is a synthetic gonadotropin-releasing hormone (GnRH) peptide agonist that binds to the GnRH receptor (GnRHR; Ki = 0.3 nM in CHO cells expressing the human receptor).{36464} It inhibits the growth of DU145, LNCaP, and PC3 prostate and OVCAR-3 ovarian cancer cells (IC50s = 62.1, 73.4, 98.1, and 67.7 μM, respectively).{52097} Triptorelin also inhibits the growth of the triple-negative breast cancer (TNBC) cell lines HCC1806 and MDA-MB-231 (EC50s = 58.29 and 31.59 μM, respectively).{52096} It stimulates follicle stimulating hormone (FSH) and luteinizing hormone (LH) release from primary rat pituitary cells when used at a concentration of 50 nM.{52097} It also decreases tumor volume of Dunning R3327H prostate tumor flank implants and reduces prostate and testis weight in rats when administered at a dose of 1 mg/kg per day.{39555} Formulations containing triptorelin have been used in the palliative treatment of advanced prostate cancer.

• Artikelnummer: CAY28613-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 28613-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK