Tropisetron (hydrochloride), CAS 105826-92-4

Formulation: A crystalline solid

Formal Name: 1H-indole-3-carboxylic acid (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, monohydrochloride

Purity: ≥98%

Formula Markup: C17H20N2O2 • HCl

Formula Weight: 320,8

Shelf life (days): 1460

CAS Number: 105826-92-4

Notes: Tropisetron is an antagonist of the serotonin (5-HT) receptor subtype 5-HT3 (Ki = 0.8 nM for the mouse receptor).{58017} It is selective for 5-HT3 over the 5-HT4 receptor subtype (Ki = 156 nM for the porcine receptor). Tropisetron is also an antagonist of the α9 nicotinic acetylcholine receptor (nAChR; IC50 = 166 nM for the rat receptor) and a partial agonist of the α7 nAChR (Ki = 6.9 nM for the rat receptor).{33370,65094} It enhances glycine-induced potentiation of homomeric α1 but not homomeric α2 glycine receptors when used at a concentration of 10 µM.{65095} Tropisetron (0.1 nM) blocks 5-HT-induced depolarizations in isolated rabbit nodose ganglia.{33371} It exhibits anti-emetic effects in a ferret model of emesis induced by cisplatin (Item No. 13119) when administered at a dose of 1 mg/kg.{46650} Formulations containing tropisetron have been used in the treatment of nausea and vomiting associated with chemotherapy.

• Artikelnummer: CAY21240-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 21240-1
• Green Labware: Nein
• Verpackungseinheit: 1 g
• Mengeneinheit: STK