Ulipristal Acetate, CAS 126784-99-4

Formulation: A crystalline solid

Formal Name: 17-(acetyloxy)-11β-[4-(dimethylamino)phenyl]-19-norpregna-4,9-diene-3,20-dione

Purity: ≥98%

Formula Markup: C30H37NO4

Formula Weight: 475,6

Shelf life (days): 1460

CAS Number: 126784-99-4

Notes: Ulipristal acetate is a selective progesterone receptor modulator (SPRM) that binds to the human progesterone receptors PR-A and PR-B (EC50s = 8.5 and 7.7 nM, respectively), rabbit uterine PR (EC50 = 13.6 nM), and rabbit thymic glucocorticoid receptor (GR; EC50 = 15.4 nM).{40657} It is selective for human progesterone receptors over the human estrogen receptor (ER; EC50 = >10,000 nM). It inhibits growth of IGROV-1 and SKOV3 human ovarian cancer cells (IC50s = 15.5 and 31.5 μM, respectively) even after resistance to combined cisplatin (Item No. 13119) and paclitaxel (Item No. 10461) treatment has developed.{40658} Ulipristal acetate reverses the proliferative effect of progesterone on patient-derived germline mutant BRCA1 breast tissue xenografts in ovariectomized athymic mice.{40659} Ulipristal acetate (40 mg/kg, i.p.) administered to female mice within 6 hours of human chorionic gonadotropin (hCG) treatment inhibits ovulation.{40660} Formulations containing ulipristal acetate have been used as emergency contraceptives and to treat uterine fibroids.

• Artikelnummer: CAY23657-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 23657-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK