Ulipristal Acetate-d6, CAS 1621894-64-1

Formulation: A solid

Formal Name: 17-(acetyloxy)-11β-[4-[di(methyl-d3)amino]phenyl]-19-norpregna-4,9-diene-3,20-dione

Purity: ≥99% deuterated forms (d1-d6)

Formula Markup: C30H31D6NO4

Formula Weight: 481,7

Shelf life (days): 1460

CAS Number: 1621894-64-1

Notes: Ulipristal acetate-d6 is intended for use as an internal standard for the quantification of ulipristal acetate (Item No. 23657) by GC- or LC-MS. Ulipristal acetate is a selective progesterone receptor modulator (SPRM) that binds to the human progesterone receptors PR-A and PR-B (EC50s = 8.5 and 7.7 nM, respectively), rabbit uterine PR (EC50 = 13.6 nM), and rabbit thymic glucocorticoid receptor (GR; EC50 = 15.4 nM).{40657} It is selective for human progesterone receptors over the human estrogen receptor (ER; EC50 = >10,000 nM). It inhibits growth of IGROV-1 and SKOV3 human ovarian cancer cells (IC50s = 15.5 and 31.5 μM, respectively) even after resistance to combined cisplatin (Item No. 13119) and paclitaxel (Item No. 10461) treatment has developed.{40658} Ulipristal acetate reverses the proliferative effect of progesterone on patient-derived germline mutant BRCA1 breast tissue xenografts in ovariectomized athymic mice.{40659} Ulipristal acetate (40 mg/kg, i.p.) administered to female mice within 6 hours of human chorionic gonadotropin (hCG) treatment inhibits ovulation.{40660} Formulations containing ulipristal acetate have been used as emergency contraceptives and to treat uterine fibroids.

• Artikelnummer: CAY26446-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 26446-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung