V-125, CAS 1807740-94-8

Formulation: A solid

Formal Name: 6-[ethyl(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)amino]-3-pyridinecarboxylic acid

Purity: ≥98%

Formula Markup: C23H30N2O2

Formula Weight: 366,5

Shelf life (days): 730

CAS Number: 1807740-94-8

Notes: V-125 is an agonist of retinoid X receptors (RXRs).{62909} It induces homodimerization of RXR in HCT116 cells in a two-hybrid assay (EC50 = 13.8 nM). V-125 selectively induces transactivation of RXRα in human RXRα-overexpressing HCT116 cells over transactivation of RARα in human RARα-overexpressing HEK293 cells when used at concentrations of 25 and 100 nM, respectively. In vivo, V-125 (80 mg/kg in the diet) inhibits vinyl carbamate-induced lung tumor growth in mice.{62910} Unlike the RXR agonist bexarotene (Item No. 11571), V-125 does not increase plasma triglyceride or cholesterol levels in mice.

• Artikelnummer: CAY37532-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37532-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: Reinstoffe