Valdecoxib-d3, CAS 1219794-90-7

Formulation: A solid

Formal Name: 4-(5-(methyl-d3)-3-phenylisoxazol-4-yl)benzenesulfonamide

Purity: ≥99% deuterated forms (d1-d3)

Formula Markup: C16H11D3N2O3S

Formula Weight: 317,4

Shelf life (days): 730

CAS Number: 1219794-90-7

Notes: Valdecoxib-d3 is intended for use as an internal standard for the quantification of valdecoxib (Item No. 10006120) by GC- or LC-MS. Valdecoxib is a selective inhibitor of COX-2 (IC50s = 0.005 and 140 µM, for human recombinant COX-2 and COX-1, respectively).{42951} It decreases LPS-induced production of prostaglandin E2 (PGE2; Item No. 14010) in isolated human whole blood (IC50 = 0.89 µM). Valdecoxib reduces carrageenan-induced paw edema and adjuvant-induced arthritis in rats (ED50s = 10.2 and 0.032 mg/kg, respectively).

• Artikelnummer: CAY28699-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 28699-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung