Vercirnon, CAS 698394-73-9

Formulation: A crystalline solid

Formal Name: N-[4-chloro-2-[(1-oxido-4-pyridinyl)carbonyl]phenyl]-4-(1,1-dimethylethyl)-benzenesulfonamide

Purity: ≥98%

Formula Markup: C22H21ClN2O4S

Formula Weight: 444,9

Shelf life (days): 1460

CAS Number: 698394-73-9

Notes: Vercirnon is an orally bioavailable antagonist of chemokine receptor 9 (CCR9) with an IC50 value of 5.4 nM for inhibition of CCL25-induced calcium mobilization in Molt-4 cells.{47155} It is selective for CCR9 over CCR1-12 and CX3CR1-7 (IC50s = >10 µM for all). It also inhibits CCL25-induced Molt-4 chemotaxis in 0.1% BSA/HBSS and in 100% human AB serum (IC50s = 3.5 and 33.4 nM, respectively), as well as chemotaxis of human T cells stimulated by retinoic acid (RA) and mouse and rat thymocytes. Vercirnon binds allosterically to the intracellular side of CCR9 and prevents G protein coupling.{47156}

• Artikelnummer: CAY23131-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 23131-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK