Vicriviroc (maleate), CAS 599179-03-0

Formulation: A crystalline solid

Formal Name: 1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]-4-[(3S)-4-[(1R)-2-methoxy-1-[4-(trifluoromethyl)phenyl]ethyl]-3-methyl-1-piperazinyl]-4-methyl-piperidine, 2Z-butenedioate

Purity: ≥98%

Formula Markup: C28H38F3N5O2 • C4H4O4

Formula Weight: 649,7

Shelf life (days): 1460

CAS Number: 599179-03-0

Notes: Vicriviroc is a chemokine (C-C motif) receptor 5 (CCR5) antagonist (Ki = 2.5 nM).{53315} It selectively inhibits CCR5 over M1 and M2 muscarinic acetylcholine receptors (Kis = >10,000 nM for both) and human-ether-a-go-go (hERG) potassium channels (IC50 = 5.8 µM).{53315} Vicriviroc decreases chemotaxis induced by chemokine (C-C motif) ligand 3 (CCL3) in Ba/F3 cells expressing recombinant human CCR5 with an IC50 value of 0.91 nM.{53316} It inhibits the replication of 30 R5-tropic HIV-1 clinical isolates in peripheral blood mononuclear cells (PBMCs; EC50s = 0.04-1.4 nM) and reduces viral entry of seven drug-resistant strains of HIV-1 in U87 cells expressing CD4 and CCR5 (EC50s = 8.7-32.9 nM).

• Artikelnummer: CAY28453-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 28453-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK