Vorapaxar, CAS 618385-01-6

Formulation: A crystalline solid

Formal Name: N-[(1R,3aR,4aR,6R,8aR,9S,9aS)-9-[(1E)-2-[5-(3-fluorophenyl)-2-pyridinyl]ethenyl]dodecahydro-1-methyl-3-oxonaphtho[2,3-c]furan-6-yl]-carbamic acid, ethyl ester

Purity: ≥98%

Formula Markup: C29H33FN2O4

Formula Weight: 492,6

Shelf life (days): 1460

CAS Number: 618385-01-6

Notes: Vorapaxar is an orally bioavailable competitive antagonist of the proteinase-activated receptor (PAR1; Ki = 8.1 nM), also known as the thrombin receptor.{37192} It is selective for PAR1 over other PARs, as well as a number of GPCRs, ion channels, and receptors. It inhibits platelet aggregation induced by thrombin (Item No. 13188) and haTRAP (IC50s = 47 and 25 nM, respectively). Vorapaxar (0.1 mg/kg, i.v.) completely inhibits platelet aggregation in cynomolgus monkeys ex vivo. Formulations containing vorapaxar are used in the prevention of thrombotic cardiovascular events.

• Artikelnummer: CAY23119-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 23119-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK