VU0152100, CAS 409351-28-6

Formulation: A crystalline solid

Formal Name: 3-amino-N-[(4-methoxyphenyl)methyl]-4,6-dimethyl-thieno[2,3-b]pyridine-2-carboxamide

Purity: ≥98%

Formula Markup: C18H19N3O2S

Formula Weight: 341,4

Shelf life (days): 1460

CAS Number: 409351-28-6

Notes: VU0152100 is a positive allosteric modulator of M4 muscarinic acetylcholine receptors.{61171} It potentiates calcium mobilization induced by acetylcholine (ACh) in CHO-K1 cells expressing the rat M4 receptor with an EC50 value of 380 nM. VU0152100 is selective for M4 over M1, M2, M3 and M5 receptors, as well as a panel of 68 additional GPCRs, ion channels, transporters, and enzymes, but does bind to the benzodiazepine binding site of the GABAA receptor at 10 µM. It reduces cocaine-induced increases in locomotor activity and cocaine self-administration in mice when administered at a dose of 1 mg/kg.{61172}

• Artikelnummer: CAY32968-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 32968-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK