VU0238429, CAS 1160247-92-6

Formulation: A solid

Formal Name: 1-[(4-methoxyphenyl)methyl]-5-(trifluoromethoxy)-1H-indole-2,3-dione

Purity: ≥98%

Formula Markup: C17H12F3NO4

Formula Weight: 351,3

Shelf life (days): 1460

CAS Number: 1160247-92-6

Notes: VU0238429 is a positive allosteric modulator of M5 muscarinic acetylcholine receptors (mAChRs; EC50 = 1.16 µM in a calcium mobilization assay).{60969} It is selective for M5 mAChRs over M1, M2, M3, and M4 mAChRs in CHO cells expressing the human receptors (EC50s = >30 µM for all in calcium mobilization assays). VU0238429 (10 mg/kg) reduces head-twitch behavior induced by the serotonin (5-HT) receptor subtype 5-HT2A agonist DOI in mice.{60970} It reverses MK-801-induced memory deficits in the novel object recognition test in mice when administered alone or in combination with the GABAB receptor positive allosteric modulator GS-39783 (Item No. 29482).

• Artikelnummer: CAY34411-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 34411-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK