VU0360172 (hydrochloride), CAS 1309976-62-2

Formulation: A crystalline solid

Formal Name: N-cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]-3-pyridinecarboxamide, monohydrochloride

Purity: ≥98%

Formula Markup: C18H15FN2O • HCl

Formula Weight: 330,8

Shelf life (days): 1460

CAS Number: 1309976-62-2

Notes: VU036172 is a positive allosteric modulator of metabotropic glutamate receptor 5 (mGluR5; Ki = 195 nM).{47575} It is selective for mGluR5 over mGluR1, mGluR3, and mGluR4 at 10 µM. VU036172 (20 and 50 µM) prevents TNF-α and nitric oxide (NO) production by IFN-γ- or LPS-stimulated BV-2 and primary microglial cells.{47576} It reduces the expression of inducible nitric oxide synthase (iNOS) and increases the expression of Ym1 and arginase 1 in LPS-stimulated BV-2 cells when used at a concentration of 20 µM. VU036172 (50 mg/kg) reduces the size of cortical lesions, prevents neuronal degeneration, and improves sensorimotor deficits in the beam walk test in a mouse model of traumatic brain injury (TBI), indicating improved recovery of motor function.

• Artikelnummer: CAY22074-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 22074-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK