VU0467154, CAS 1451993-15-9

Formulation: A solid

Formal Name: 5-amino-3,4-dimethyl-N-[[4-[(trifluoromethyl)sulfonyl]phenyl]methyl]-thieno[2,3-c]pyridazine-6-carboxamide

Purity: ≥95%

Formula Markup: C17H15F3N4O3S2

Formula Weight: 444,5

Shelf life (days): 1460

CAS Number: 1451993-15-9

Notes: VU0467154 is a positive allosteric modulator of the M4 muscarinic acetylcholine receptor that potentiates acetylcholine responses in CHO cells expressing M4 receptors (EC50s = 17.7, 630, and 1,000 nM for rat, human, and cynomolgus monkey receptors, respectively).{41907} It is selective for M4 over M1-3 and M5 receptors and a panel of receptors, transporters, and cation channels when used at a concentration of 10 µM. In vivo, VU0467154 (3-56.6 mg/kg, p.o.) reverses amphetamine-induced hyperlocomotion in rats. It reverses MK-801-induced hyperlocomotion, deficits in a pairwise visual discrimination task, and impairments in the acquisition of contextual fear conditioning in wild-type, but not M4 knockout, mice. VU0467154 (3-30 mg/kg) also increases freezing behavior in contextual and tone fear conditioning tests in wild-type mice when administered prior to the conditioning session. Chronic administration of VU0467154 (10 mg/kg once daily) reduces motor incoordination and prevents decreases in locomotion in the YAC128 transgenic mouse model of Huntington's disease.{41908}

• Artikelnummer: CAY25555-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 25555-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK