Notes: VU0469650 is a brain-penetrant negative allosteric modulator of metabotropic glutamate receptor 1 (mGluR1).{54670} It inhibits glutamate-induced calcium flux in cells expressing human mGluR1 (IC50 = 99 nM). VU0469650 is greater than 100-fold selective for mGluR1 over mGluR2-8 at 10 µM.