WS-12, CAS 68489-09-8

Formulation: A crystalline solid

Formal Name: (1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-(1-methylethyl)-cyclohexanecarboxamide

Purity: ≥98%

Formula Markup: C18H27NO2

Formula Weight: 289,4

Shelf life (days): 1460

CAS Number: 68489-09-8

Notes: WS-12 is an agonist of transient receptor potential melastatin 8 (TRPM8).{45846} It induces currents in Xenopus oocytes expressing mouse TRPM8 (EC50 = 12 µM) and is selective for TRPM8 over transient receptor potential vanilloid 1-4 (TRPV1-4) and transient receptor potential ankyrin 1 (TRPA1) at 1 mM. WS-12 (6 nmol, i.c.v.) reduces nocifensive behavior induced by capsaicin (Item Nos. 92350 / 10010743) in wild-type, but not Trpm8-/-, mice.{45847} It induces analgesia in the hot plate test, an effect that can be reversed by the opioid receptor antagonist naloxone, in mice.

• Artikelnummer: CAY30352-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 30352-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK