Wy 14643, CAS 50892-23-4

Formulation: A crystalline solid

Formal Name: 2-[[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]-acetic acid

Purity: ≥98%

Formula Markup: C14H14ClN3O2S

Formula Weight: 323,8

Shelf life (days): 1460

CAS Number: 50892-23-4

Notes: Wy 14643 is an agonist of peroxisome proliferator-activated receptor α (PPARα).{4044} It selectively transactivates PPARα over PPARγ in a reporter assay using CV-1 mouse fibroblasts when used at a concentration of 100 µM. Wy 14643 (2 mg/kg) decreases distal colon protein levels of IFN-γ, TNF-α, IL-1β, and IL-6 in a mouse model of experimental colitis induced by dextran sulfate sodium (DSS; Item No. 23250).{62963} Wy 14643 (0.1% w/w in the diet) reduces hepatic triglycerides, leukocyte recruitment, and fibrosis in a mouse model of methionine- and choline-deficient diet-induced steatohepatitis.{62962}

• Artikelnummer: CAY70730-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 70730-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK