YK-11, CAS 1370003-76-1

Formulation: A crystalline solid

Formal Name: (20E)-17α,20-[(1-methoxyethylidene)bis(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid, methyl ester

Purity: ≥95% (mixture of diastereomers)

Formula Markup: C25H34O6

Formula Weight: 430,5

Shelf life (days): 1460

CAS Number: 1370003-76-1

Notes: YK-11 is an androgen receptor partial agonist that activates androgen receptor transcriptional activity in HEK293 cells overexpressing androgen receptors when used at a concentration of 0.1 μM.{48154} It induces expression of the androgen receptor target genes FKBP51 and FGF18 in HEK293 cells when used at a concentration of 10 μM. YK-11 accelerates nuclear translocation of androgen receptors without inducing interaction between the androgen receptor N- and C-termini. In C2C12 cells, YK-11 (500 nM) increases expression of the myogenic regulatory factors MyoD, Myf5, and myogenin, as well as follistatin (Fst), and induces myogenic differentiation.{48155} YK-11 also accelerates proliferation and mineralization and increases expression of the osteoblast differentiation markers osteoprotegerin and osteocalcin in MC3T3-E1 mouse osteoblast cells.{48156}

• Artikelnummer: CAY9003137-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 9003137-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK