YM-298198 (hydrochloride), CAS 1216398-09-2

Formulation: A crystalline solid

Formal Name: 6-amino-N-cyclohexyl-N,3-dimethyl-thiazolo[3,2-a]benzimidazole-2-carboxamide, monohydrochloride

Purity: ≥98%

Formula Markup: C18H22N4OS • HCl

Formula Weight: 378,9

Shelf life (days): 1460

CAS Number: 1216398-09-2

Notes: YM-298198 is a non-competitive antagonist of the metabotropic glutamate receptor type I (mGluR1; Ki = 19 nM).{38955} It is selective for mGluR1 over mGluR2-7 (IC50s = 0.016 and >10 μM, respectively). YM-298198 binds to rat cerebellum membranes (Ki = 20 nM). In vivo, YM-298198 (10 and 30 mg/kg, p.o.) increases nociceptive response latency in a mouse model of hyperalgesia induced by streptozotocin (Item No. 13104) without affecting motor coordination in a rotarod test. YM-298198 also reduces reinstatement of drug-seeking behavior induced by cocaine priming in rats.{38956}

• Artikelnummer: CAY22925-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 22925-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK