Z944, CAS 1199236-64-0

Formulation: A solid

Formal Name: 4-[[(3-chloro-5-fluorobenzoyl)amino]methyl]-N-(1,1-dimethylethyl)-1-piperidineacetamide

Purity: ≥98%

Formula Markup: C19H27ClFN3O2

Formula Weight: 383,9

Shelf life (days): 1460

CAS Number: 1199236-64-0

Notes: Z944 is an inhibitor of T-type calcium channels (IC50s = 0.050-0.160 µM for the human recombinant voltage-gated calcium (Cav) channels Cav3.1, Cav3.2, and Cav3.3).{52410} It is selective for T-type channels over the N-type Cav2.2 channel (IC50 = 11 µM), as well as the rat L-type Cav1.2, human-ether-a-go-go (hERG/Kv11.1) potassium, and human voltage-gated sodium (Nav) channel Nav1.5 (IC50s = 32, 7.8, and 100 µM, respectively). Z944 (30 mg/kg) reduces the seizure duration and the amount of time rats spend in seizures in a model of absence epilepsy. It delays seizure progression in amygdala-kindled rats but does not inhibit seizures in fully kindled rats.{52411}

• Artikelnummer: CAY27679-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 27679-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK